Pentobarbital will reduce the level or impact of fosamprenavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. pentobarbital will minimize the extent or result of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with powerful CYP3A4 inducers can lead to decreased serum concentrations and lack of a... https://norwichj899pcm3.wikitron.com/user