51 nM. These types of discovering points out the exceptional position of methylene linker incorporated concerning the terminal phenyl and substituted piperazine in enhancing BCR-ABLWT inhibition, which can stem from the flexibility of extended piperazine moiety to form limited interactions with the allosteric site of ABL. The N 2.two.eight was https://indazole-products19752.jiliblog.com/88256704/indazole-no-further-a-mystery