Higher glucose links to dysfunctions of glucose uptake and catabolism and induces substantial oxidative anxiety, dysfunction of endothelial cells. Large blood pressure contributes to cardiac and vascular damage. Central obesity is relevant to maldistribution of totally free fatty acid, overproduction of inflammatory molecules, and leptin resistance [21]. the editor(s) disclaim https://www.directivepublications.org/journal-of-cardiovascular-diseases/